MTIF2

Across TCGA patient cohorts, MTIF2 mutation is significantly associated with the RNA expression of many other genes, with 1,620 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTIF2-associated genes across cancer lineages are OR2T29, RPL7AP23, and RNU6-715P. Each is linked with MTIF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTIF2-to-partner and partner-to-MTIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T29 grouped by MTIF2-low versus MTIF2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTIF2→partner) and Y-score (partner→MTIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	OR2T29 →	+0.040	+5.226	<.001	.003	3	3
CESC	RPL7AP23 →	+0.041	+3.688	<.001	.004	3	2
BLCA	RNU6-715P →	+0.229	+4.040	<.001	.007	3	2
BLCA	RN7SKP204 →	+0.115	+3.188	.002	.007	3	2
BLCA	RNU6-748P →	+0.365	+2.607	.004	.005	3	2
BLCA	IGHD6-13 →	+0.888	+3.453	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,620 associations by consensus.

OR2T29 by MTIF2 expression — STAD

Explore this box plot interactively →