MTIF2

Across TCGA patient cohorts, MTIF2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTIF2-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and PCNA. Each is linked with MTIF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTIF2-to-partner and partner-to-MTIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MTIF2-low versus MTIF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTIF2→partner) and Y-score (partner→MTIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.472	-2.321	.007	.033	3	3
UCEC	Caspase-7-cleavedD198 →	+0.983	+4.019	<.001	<.001	3	3
UCEC	PCNA →	+0.222	+1.765	.006	.014	3	2
UCEC	DJ-1 →	+0.129	+1.750	.038	.049	3	2
UCEC	14-3-3_beta →	-0.096	-3.143	.010	.018	3	1
UCEC	eEF2 →	+0.321	+3.321	.016	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PDCD4 by MTIF2 expression — UCEC

Explore this box plot interactively →