MTIF2

Across TCGA cell cohorts, MTIF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,947 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MTIF2-associated GO terms across cancer lineages are Formation of translation preinitiation complex, Regulation of mitochondrial RNA catabolic process, and Positive regulation of translational elongation. Each is linked with MTIF2 in more than 16 cancer types. Because this analysis shows association rather than direction, both MTIF2-to-partner and partner-to-MTIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formation of translation preinitiation complex grouped by MTIF2-low versus MTIF2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTIF2→partner) and Y-score (partner→MTIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Formation of translation preinitiation complex →	+0.137	+0.555	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of mitochondrial RNA catabolic process →	+0.140	+0.892	<.001	<.001	3	17
LUNG_SCLC	Positive regulation of translational elongation →	+0.115	+0.513	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Mitochondrial mRNA polyadenylation →	+0.139	+0.956	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Methylation →	+0.062	+1.017	<.001	<.001	3	14
BLOOD_Lymphoma	Mitochondrial tRNA modification →	+0.103	+0.768	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,947 associations by consensus.

Formation of translation preinitiation complex by MTIF2 expression — LUNG_SCLC

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