MTIF2

Across TCGA cell cohorts, MTIF2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible MTIF2-associated genes across cancer lineages are HTR3D, VCY1B, and VCY. Each is linked with MTIF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTIF2-to-partner and partner-to-MTIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTR3D grouped by MTIF2-low versus MTIF2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTIF2→partner) and Y-score (partner→MTIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	HTR3D →	+0.012	+4.662	<.001	.003	3	1
LUNG_NSCLC_LUSC	VCY1B →	+0.062	+4.108	.001	.005	3	1
LUNG_NSCLC_LUSC	VCY →	+0.062	+4.108	.001	.005	3	1
LUNG_NSCLC_LUSC	OR6V1 →	+0.072	+4.584	<.001	.001	3	1
LUNG_NSCLC_LUSC	WNT8A →	+0.069	+4.108	<.001	.005	3	1
LARGE_INTESTINE	ACSM6 →	+0.033	+4.584	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HTR3D by MTIF2 expression — BLOOD_Lymphoma

Explore this box plot interactively →