MTHFSD

Across TCGA pan-cancer cohorts, MTHFSD mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MTHFSD data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTHFSD mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTHFSD expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and CCRCC are the cancer types where MTHFSD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.946	0.545	.007	27	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.401	.024	4	view →
CCRCC	DFS	Median	II,III,IV	0.317	0.838	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MTHFSD–HNSC (DFS)

Open the HNSC breakdown →