MTHFSD

Across TCGA pan-cancer cohorts, MTHFSD mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MTHFSD’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MTHFSD mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MTHFSD is over-expressed in tumor, although a few such as OV show the opposite, repressed pattern.

LUAD, CCRCC, and OV are the cancer types where MTHFSD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTHFSD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.172	.001	6	view →
CCRCC	All	All	+0.112	<.001	6	view →
OV	All	All	−0.732	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MTHFSD–LUAD

Open the LUAD breakdown →