MTHFSD

Across TCGA patient cohorts, MTHFSD mutation is significantly associated with the RNA expression of many other genes, with 1,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFSD-associated genes across cancer lineages are RNU6-618P, PSAT1P4, and CKS1BP5. Each is linked with MTHFSD in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFSD-to-partner and partner-to-MTHFSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-618P grouped by MTHFSD-low versus MTHFSD-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFSD→partner) and Y-score (partner→MTHFSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-618P →	+0.328	+3.271	.001	.009	3	2
COAD	PSAT1P4 →	+0.245	+3.785	<.001	.001	3	2
UCEC	CKS1BP5 →	+0.142	+2.613	<.001	.006	3	2
SKCM	UBL5P3 →	+0.130	+5.408	<.001	.002	3	2
BRCA	RNA5SP404 →	+0.197	+7.731	<.001	.009	3	1
BRCA	MIR4303 →	+0.517	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,659 associations by consensus.

RNU6-618P by MTHFSD expression — COAD

Explore this box plot interactively →