MTHFSD

Across TCGA patient cohorts, MTHFSD mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFSD-associated genes across cancer lineages are eEF2, MEK1, and PCNA. Each is linked with MTHFSD in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFSD-to-partner and partner-to-MTHFSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MTHFSD-low versus MTHFSD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFSD→partner) and Y-score (partner→MTHFSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.387	+3.169	.010	.018	3	2
UCEC	MEK1 →	+0.524	+3.700	<.001	.001	3	2
UCEC	PCNA →	+0.348	+4.000	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.321	-4.000	.002	<.001	3	1
UCEC	ER-alpha →	-0.778	-2.986	.025	.035	3	1
UCEC	ERK2 →	+0.216	+1.700	.008	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by MTHFSD expression — UCEC

Explore this box plot interactively →