MTHFSD

Across TCGA cell cohorts, MTHFSD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,886 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTHFSD-associated GO terms across cancer lineages are Regulation of mRNA processing, Regulation of mRNA splicing, via spliceosome, and mRNA transport. Each is linked with MTHFSD in more than 15 cancer types. Because this analysis shows association rather than direction, both MTHFSD-to-partner and partner-to-MTHFSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA processing grouped by MTHFSD-low versus MTHFSD-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFSD→partner) and Y-score (partner→MTHFSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA processing →	+0.097	+0.900	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA splicing, via spliceosome →	+0.092	+0.820	<.001	.001	3	15
BONE	mRNA transport →	+0.132	+0.912	<.001	<.001	2	16
BONE	mRNA export from nucleus →	+0.129	+0.884	<.001	.001	2	16
UPPER_AERODIGESTIVE_TRACT	Viral transcription →	+0.115	+0.768	.002	.009	3	15
UPPER_AERODIGESTIVE_TRACT	Post-transcriptional gene silencing →	+0.097	+0.953	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,886 associations by consensus.

Regulation of mRNA processing by MTHFSD expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →