MTHFSD

Across TCGA cell cohorts, MTHFSD mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTHFSD-associated genes across cancer lineages are FCN2, OR1E1, and OR52E8. Each is linked with MTHFSD in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFSD-to-partner and partner-to-MTHFSD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCN2 grouped by MTHFSD-low versus MTHFSD-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFSD→partner) and Y-score (partner→MTHFSD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FCN2 →	+0.060	+4.807	<.001	.006	3	2
BLOOD_Myeloma	OR1E1 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR52E8 →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Leukemia	DEFB4A →	+0.086	+3.269	<.001	.007	3	1
BLOOD_Leukemia	L1TD1 →	+1.266	+3.177	<.001	.004	3	1
BLOOD_Leukemia	C6 →	+0.083	+3.507	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FCN2 by MTHFSD expression — BLOOD_Myeloma

Explore this box plot interactively →