MTHFS

Across TCGA pan-cancer cohorts, MTHFS Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MTHFS data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTHFS Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MTHFS expression acts as an unfavorable survival marker.

HNSC, COAD, and SARC are the cancer types where MTHFS Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.769	<.001	48	view →
COAD	OS	Median	All	0.001	0.871	<.001	24	view →
SARC	OS	Median	All	0.108	0.839	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MTHFS–HNSC (OS)

Open the HNSC breakdown →