MTHFS

Across TCGA pan-cancer cohorts, MTHFS mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MTHFS data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MTHFS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTHFS expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and OV are the cancer types where MTHFS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.937	0.504	<.001	17	view →
HNSC	DFS	Quartile	II,III,IV	0.872	0.508	.004	17	view →
OV	DFS	Median	All	0.654	0.923	.035	8	view →
PDAC	OS	Quartile	All	0.484	0.788	.016	4	view →
GBM	DFS	Quartile	All	0.681	0.912	.008	2	view →
LUAD	DFS	Quartile	All	0.962	0.891	.042	1	view →
LSCC	DFS	Tertile	II,III,IV	0.827	1.000	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MTHFS–CCRCC (DFS)

Open the CCRCC breakdown →