MTHFS

Across TCGA pan-cancer cohorts, MTHFS mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MTHFS’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MTHFS mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MTHFS is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and LUAD are the cancer types where MTHFS tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTHFS mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−1.470	<.001	11	view →
PDAC	Female	II,III,IV	−1.585	<.001	6	view →
LUAD	Female	All	+0.356	<.001	3	view →
COAD	Male	II,III,IV	+0.967	.032	2	view →
LSCC	All	All	+0.176	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MTHFS–CCRCC

Open the CCRCC breakdown →