MTHFS

Across TCGA cell cohorts, MTHFS RNA expression is significantly associated with the RNA expression of many other genes, with 8,292 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MTHFS-associated genes across cancer lineages are MRPL46, PSMA4, and COX5A. Each is linked with MTHFS in more than 12 cancer types. Because this analysis shows association rather than direction, both MTHFS-to-partner and partner-to-MTHFS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTHFS versus MRPL46 in OVARY, with a Pearson correlation of 0.58.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFS→partner) and Y-score (partner→MTHFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MRPL46 →	+0.958	+1.084	<.001	<.001	3	13
OVARY	PSMA4 →	+0.914	+1.256	<.001	<.001	2	13
OESOPHAGUS	COX5A →	+0.976	+0.827	.003	.005	1	13
UPPER_AERODIGESTIVE_TRACT	ZFAND6 →	+0.877	+0.849	<.001	<.001	3	11
OVARY	RAMAC →	+0.722	+0.975	<.001	<.001	3	10
URINARY_TRACT	MESD →	+0.794	+1.162	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,292 associations by consensus.

MTHFS vs MRPL46 — OVARY

Explore this scatter interactively →