MTHFS

Across TCGA cell cohorts, MTHFS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,322 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MTHFS-associated GO terms across cancer lineages are Formate metabolic process, Tetrahydrofolate interconversion, and Folic acid-containing compound biosynthetic process. Each is linked with MTHFS in more than 13 cancer types. Because this analysis shows association rather than direction, both MTHFS-to-partner and partner-to-MTHFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formate metabolic process grouped by MTHFS-low versus MTHFS-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFS→partner) and Y-score (partner→MTHFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Formate metabolic process →	+0.145	+1.347	<.001	<.001	3	14
CNS	Tetrahydrofolate interconversion →	+0.128	+0.864	<.001	<.001	3	12
BLOOD_Myeloma	Folic acid-containing compound biosynthetic process →	+0.103	+0.816	.003	<.001	3	10
LUNG_SCLC	Pteridine-containing compound biosynthetic process →	+0.143	+0.697	<.001	<.001	3	10
LARGE_INTESTINE	Tetrahydrofolate metabolic process →	+0.078	+0.476	.008	.002	3	8
BONE	One-carbon metabolic process →	+0.108	+1.347	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,322 associations by consensus.

Formate metabolic process by MTHFS expression — BLOOD_Lymphoma

Explore this box plot interactively →