MTHFR

Across TCGA patient cohorts, MTHFR mutation is significantly associated with the RNA expression of many other genes, with 2,833 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFR-associated genes across cancer lineages are MIR1915, PLGRKT, and RAC2. Each is linked with MTHFR in more than 2 cancer types. Because this analysis shows association rather than direction, both MTHFR-to-partner and partner-to-MTHFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1915 grouped by MTHFR-low versus MTHFR-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFR→partner) and Y-score (partner→MTHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR1915 →	+0.921	+5.203	<.001	.007	3	3
UCEC	PLGRKT →	+0.409	+1.818	.007	<.001	3	3
COAD	RAC2 →	+0.829	+3.348	.002	.005	3	3
UCEC	LILRB2 →	+0.599	+1.584	<.001	.002	3	3
UCEC	CCL4 →	+1.080	+2.653	<.001	<.001	3	3
UCEC	SEC13 →	+0.255	+1.888	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,833 associations by consensus.

MIR1915 by MTHFR expression — BRCA

Explore this box plot interactively →