MTHFR

Across TCGA patient cohorts, MTHFR mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFR-associated genes across cancer lineages are mTOR_pS2448, ERK2, and Lck. Each is linked with MTHFR in more than 2 cancer types. Because this analysis shows association rather than direction, both MTHFR-to-partner and partner-to-MTHFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by MTHFR-low versus MTHFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFR→partner) and Y-score (partner→MTHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.094	-1.787	.047	.026	3	3
UCEC	ERK2 →	+0.192	+2.169	.001	.003	3	2
UCEC	Lck →	+0.141	+1.678	.028	.021	3	2
UCEC	Notch1 →	+0.146	+1.523	.001	.008	3	2
UCEC	PDCD4 →	-0.404	-1.523	.007	.008	3	2
UCEC	PKC-a →	+0.392	+2.515	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

mTOR_pS2448 by MTHFR expression — UCEC

Explore this box plot interactively →