MTHFR

Across TCGA cell cohorts, MTHFR RNA expression is significantly associated with the go_rna of many other GO terms, with 5,060 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MTHFR-associated GO terms across cancer lineages are Vacuole organization, Regulation of macroautophagy, and Negative regulation of transcription by RNA polymerase III. Each is linked with MTHFR in more than 16 cancer types. Because this analysis shows association rather than direction, both MTHFR-to-partner and partner-to-MTHFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuole organization grouped by MTHFR-low versus MTHFR-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFR→partner) and Y-score (partner→MTHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Vacuole organization →	+0.049	+0.752	<.001	.001	3	17
OESOPHAGUS	Regulation of macroautophagy →	+0.091	+1.598	<.001	<.001	3	17
KIDNEY	Negative regulation of transcription by RNA polymerase III →	+0.127	+0.882	.001	.008	3	16
OESOPHAGUS	Regulation of TORC1 signaling →	+0.069	+1.505	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.098	+0.983	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.068	+1.165	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,060 associations by consensus.

Vacuole organization by MTHFR expression — SKIN

Explore this box plot interactively →