MTHFR

Across TCGA cell cohorts, MTHFR mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTHFR-associated genes across cancer lineages are OR13D1, MBD3L3, and IL22. Each is linked with MTHFR in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFR-to-partner and partner-to-MTHFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13D1 grouped by MTHFR-low versus MTHFR-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFR→partner) and Y-score (partner→MTHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR13D1 →	+0.068	+4.066	<.001	.002	3	1
BLOOD_Leukemia	MBD3L3 →	+0.033	+3.289	<.001	.009	3	1
STOMACH	IL22 →	+0.046	+5.285	<.001	.003	3	1
STOMACH	LRRC72 →	+0.093	+5.285	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CRYGA →	+0.077	+4.736	<.001	.009	3	1
LARGE_INTESTINE	TRIM37 →	+0.595	+3.212	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

OR13D1 by MTHFR expression — BLOOD_Leukemia

Explore this box plot interactively →