MTHFD2P6

Across TCGA patient cohorts, MTHFD2P6 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,185 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MTHFD2P6-associated GO terms across cancer lineages are Positive regulation of DNA metabolic process, Telomere maintenance via telomere lengthening, and Protein polyubiquitination. Each is linked with MTHFD2P6 in more than 15 cancer types. Because this analysis shows association rather than direction, both MTHFD2P6-to-partner and partner-to-MTHFD2P6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA metabolic process grouped by MTHFD2P6-low versus MTHFD2P6-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2P6→partner) and Y-score (partner→MTHFD2P6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of DNA metabolic process →	+0.063	+0.148	<.001	.001	3	16
STAD	Telomere maintenance via telomere lengthening →	+0.048	+0.078	<.001	<.001	3	15
ESCA	Protein polyubiquitination →	+0.062	+0.175	<.001	.001	3	15
ESCA	Obsolete regulation of histone modification →	+0.038	+0.085	.001	<.001	3	15
ESCA	Negative regulation of DNA metabolic process →	+0.042	+0.126	.004	<.001	3	15
ESCA	Regulation of telomerase activity →	+0.054	+0.139	.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,185 associations by consensus.

Positive regulation of DNA metabolic process by MTHFD2P6 expression — ESCA

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