Across TCGA pan-cancer cohorts, MTHFD2P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTHFD2P2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MTHFD2P2 RNA is repressed in tumor relative to normal tissue. In most cancer types MTHFD2P2 is over-expressed in tumor, although a few such as THCA and ESCA show the opposite, repressed pattern.

THCA and ESCA are the cancer types where MTHFD2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MTHFD2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.042	.047	2	view →
ESCA	All	All	−0.493	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: MTHFD2P2 RNA expression & survival · all MTHFD2P2 data types