MTHFD2P1

Across TCGA patient cohorts, MTHFD2P1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible MTHFD2P1-associated genes across cancer lineages are PCNA, XRCC1, and 4E-BP1_pS65. Each is linked with MTHFD2P1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTHFD2P1-to-partner and partner-to-MTHFD2P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MTHFD2P1-low versus MTHFD2P1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2P1→partner) and Y-score (partner→MTHFD2P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PCNA →	+0.318	+2.820	<.001	.035	3	3
LUAD	XRCC1 →	+0.200	+2.832	.006	.034	3	2
LUAD	4E-BP1_pS65 →	+0.203	+3.182	.003	.009	3	2
LUSC	Caveolin-1 →	-0.609	-3.000	.045	.035	3	2
LUAD	PKC-b-II_pS660 →	-0.446	-3.321	.022	.010	3	1
LUSC	FoxM1 →	+0.278	+2.179	.037	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PCNA by MTHFD2P1 expression — LUAD

Explore this box plot interactively →