MTHFD2

Across TCGA patient cohorts, MTHFD2 mutation is significantly associated with the RNA expression of many other genes, with 1,020 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFD2-associated genes across cancer lineages are MIR4445, BLOC1S2P1, and GAPDHP56. Each is linked with MTHFD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTHFD2-to-partner and partner-to-MTHFD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4445 grouped by MTHFD2-low versus MTHFD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2→partner) and Y-score (partner→MTHFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4445 →	+0.201	+4.671	<.001	.002	3	3
COAD	BLOC1S2P1 →	+0.370	+5.080	<.001	.008	3	2
CESC	GAPDHP56 →	+0.041	+5.569	<.001	.002	3	2
UCEC	RPS3AP17 →	+0.070	+2.539	.006	.003	3	2
SKCM	SMR3A →	+1.200	+6.199	<.001	.001	3	2
COAD	ATP5PBP2 →	+0.357	+5.017	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,020 associations by consensus.

MIR4445 by MTHFD2 expression — UCEC

Explore this box plot interactively →