MTHFD2

Across TCGA patient cohorts, MTHFD2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTHFD2-associated genes across cancer lineages are FoxM1, INPP4B, and Notch1. Each is linked with MTHFD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFD2-to-partner and partner-to-MTHFD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MTHFD2-low versus MTHFD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2→partner) and Y-score (partner→MTHFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.350	+2.321	.007	.035	3	1
UCEC	INPP4B →	-0.335	-2.999	.039	.035	3	1
UCEC	Notch1 →	+0.186	+3.179	.008	.010	3	1
UCEC	STAT3_pY705 →	-0.522	-2.321	<.001	.035	3	1
UCEC	Stathmin →	+0.193	+2.833	.005	.034	3	1
UCEC	Caspase-8 →	-0.276	-3.459	.028	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FoxM1 by MTHFD2 expression — UCEC

Explore this box plot interactively →