MTHFD2

Across TCGA cell cohorts, MTHFD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,329 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTHFD2-associated GO terms across cancer lineages are Formate biosynthetic process, Serine family amino acid biosynthetic process, and L-alanine catabolic process. Each is linked with MTHFD2 in more than 17 cancer types. Because this analysis shows association rather than direction, both MTHFD2-to-partner and partner-to-MTHFD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Formate biosynthetic process grouped by MTHFD2-low versus MTHFD2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD2→partner) and Y-score (partner→MTHFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Formate biosynthetic process →	+0.187	+1.411	.001	.003	3	18
LARGE_INTESTINE	Serine family amino acid biosynthetic process →	+0.220	+1.262	<.001	<.001	3	14
BONE	L-alanine catabolic process →	+1.195	+1.150	<.001	<.001	3	13
PANCREAS	Proteinogenic amino acid biosynthetic process →	+0.151	+1.514	<.001	<.001	3	13
STOMACH	L-aspartate biosynthetic process →	+0.244	+1.558	<.001	<.001	3	13
BLOOD_Leukemia	L-serine biosynthetic process →	+0.206	+0.896	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,329 associations by consensus.

Formate biosynthetic process by MTHFD2 expression — OESOPHAGUS

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