MTHFD1

Across TCGA pan-cancer cohorts, MTHFD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MTHFD1 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MTHFD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MTHFD1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where MTHFD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.809	0.220	.001	45	view →
LUAD	OS	Quartile	All	0.643	1.000	.009	10	view →
HNSC	DFS	Median	III,IV	0.735	0.519	.021	9	view →
PDAC	DFS	Quartile	All	0.466	0.328	.045	2	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.776	.012	1	view →
GBM	OS	Quartile	All	0.966	0.827	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MTHFD1–CCRCC (DFS)

Open the CCRCC breakdown →