MTHFD1

Across TCGA patient cohorts, MTHFD1 protein abundance is significantly associated with the RNA expression of many other genes, with 11,786 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MTHFD1-associated genes across cancer lineages are TIMM9, TRMT5, and ERH. Each is linked with MTHFD1 in more than 9 cancer types. Because this analysis shows association rather than direction, both MTHFD1-to-partner and partner-to-MTHFD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MTHFD1 versus TIMM9 in HNSC, with a Pearson correlation of 0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1→partner) and Y-score (partner→MTHFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TIMM9 →	+0.703	+0.288	<.001	<.001	3	10
HNSC	TRMT5 →	+0.591	+0.358	<.001	<.001	3	10
HNSC	ERH →	+0.699	+0.255	.003	<.001	3	9
HNSC	EIF2S1 →	+0.565	+0.308	<.001	<.001	3	9
COAD	WDR89 →	+0.499	+0.287	.001	<.001	3	9
HNSC	GLRX5 →	+0.518	+0.251	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,786 associations by consensus.

MTHFD1 vs TIMM9 — HNSC

Explore this scatter interactively →