MTHFD1

Across TCGA cell cohorts, MTHFD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,167 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTHFD1-associated GO terms across cancer lineages are DNA strand elongation, Replication fork processing, and Homologous recombination. Each is linked with MTHFD1 in more than 17 cancer types. Because this analysis shows association rather than direction, both MTHFD1-to-partner and partner-to-MTHFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by MTHFD1-low versus MTHFD1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1→partner) and Y-score (partner→MTHFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.177	+1.563	<.001	<.001	3	18
BONE	Replication fork processing →	+0.161	+1.221	<.001	.001	3	18
OESOPHAGUS	Homologous recombination →	+0.108	+1.269	.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Meiotic cell cycle →	+0.094	+1.473	<.001	.001	3	18
BONE	DNA replication →	+0.150	+1.003	.001	.008	3	18
OESOPHAGUS	DNA replication initiation →	+0.191	+1.303	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,167 associations by consensus.

DNA strand elongation by MTHFD1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →