MTHFD1

Across TCGA cell cohorts, MTHFD1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MTHFD1-associated genes across cancer lineages are OTOR, OR5C1, and CLEC14A. Each is linked with MTHFD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTHFD1-to-partner and partner-to-MTHFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTOR grouped by MTHFD1-low versus MTHFD1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTHFD1→partner) and Y-score (partner→MTHFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	OTOR →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	OR5C1 →	+0.035	+5.044	<.001	<.001	3	1
URINARY_TRACT	CLEC14A →	+0.024	+4.217	<.001	.005	3	1
URINARY_TRACT	PRAMEF9 →	+0.010	+4.087	<.001	.009	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	MAGEB1 →	+0.189	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

OTOR by MTHFD1 expression — URINARY_TRACT

Explore this box plot interactively →