MTG2

Across TCGA patient cohorts, MTG2 mutation is significantly associated with the RNA expression of many other genes, with 2,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTG2-associated genes across cancer lineages are MCM5, RBBP8, and ERI1. Each is linked with MTG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTG2-to-partner and partner-to-MTG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM5 grouped by MTG2-low versus MTG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTG2→partner) and Y-score (partner→MTG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MCM5 →	+0.464	+2.931	.007	<.001	3	2
UCEC	RBBP8 →	+0.539	+2.595	.005	.005	3	2
UCEC	ERI1 →	+0.609	+3.928	<.001	<.001	3	2
UCEC	LEPROTL1 →	+0.388	+2.180	.001	<.001	3	2
UCEC	NCAPG →	+0.800	+3.818	<.001	<.001	3	2
UCEC	ABHD5 →	+0.480	+2.158	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,409 associations by consensus.

MCM5 by MTG2 expression — UCEC

Explore this box plot interactively →