MTG2

Across TCGA patient cohorts, MTG2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTG2-associated genes across cancer lineages are Rad50, ATM, and EGFR_pY1173. Each is linked with MTG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTG2-to-partner and partner-to-MTG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by MTG2-low versus MTG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTG2→partner) and Y-score (partner→MTG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.205	-2.222	.014	.010	3	2
UCEC	ATM →	-0.513	-2.102	.001	.016	3	2
UCEC	EGFR_pY1173 →	+0.069	+1.720	.013	.025	3	1
UCEC	A-Raf_pS299 →	-0.129	-1.906	.001	.015	3	1
UCEC	FoxM1 →	+0.189	+1.440	.034	.024	3	1
UCEC	GATA6 →	-0.112	-1.355	.040	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rad50 by MTG2 expression — UCEC

Explore this box plot interactively →