MTG2

Across TCGA cell cohorts, MTG2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,150 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MTG2-associated GO terms across cancer lineages are Regulation of telomeric loop disassembly, Promoter clearance during DNA-templated transcription, and RNA polymerase II promoter clearance. Each is linked with MTG2 in more than 13 cancer types. Because this analysis shows association rather than direction, both MTG2-to-partner and partner-to-MTG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomeric loop disassembly grouped by MTG2-low versus MTG2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTG2→partner) and Y-score (partner→MTG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of telomeric loop disassembly →	+0.137	+0.732	<.001	.004	3	14
KIDNEY	Promoter clearance during DNA-templated transcription →	+0.130	+0.729	.001	.004	3	12
KIDNEY	RNA polymerase II promoter clearance →	+0.130	+0.729	.001	.004	3	12
SKIN	Negative regulation of t-circle formation →	+0.128	+0.998	<.001	<.001	3	12
SOFT_TISSUE	Spliceosomal tri-snRNP complex assembly →	+0.096	+0.741	<.001	.001	3	12
BONE	Pre-mRNA catabolic process →	+0.289	+0.789	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,150 associations by consensus.

Regulation of telomeric loop disassembly by MTG2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →