MTFR2

Across TCGA patient cohorts, MTFR2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTFR2-associated genes across cancer lineages are ATM, Bak, and Rab25. Each is linked with MTFR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTFR2-to-partner and partner-to-MTFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MTFR2-low versus MTFR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTFR2→partner) and Y-score (partner→MTFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.542	-3.321	.022	.010	1	3
UCEC	Bak →	+0.277	+3.000	.035	.036	2	2
UCEC	Rab25 →	-0.437	-3.321	.011	.010	2	1
UCEC	c-Kit →	-0.267	-3.321	.028	.010	2	1
UCEC	CD49b →	-0.425	-3.308	.004	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

ATM by MTFR2 expression — UCEC

Explore this box plot interactively →