MTFR2

Across TCGA cell cohorts, MTFR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,439 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MTFR2-associated GO terms across cancer lineages are Regulation of mitotic sister chromatid separation, Negative regulation of ubiquitin protein ligase activity, and Regulation of chromosome separation. Each is linked with MTFR2 in more than 17 cancer types. Because this analysis shows association rather than direction, both MTFR2-to-partner and partner-to-MTFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitotic sister chromatid separation grouped by MTFR2-low versus MTFR2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MTFR2→partner) and Y-score (partner→MTFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of mitotic sister chromatid separation →	+0.156	+1.235	<.001	<.001	3	18
OESOPHAGUS	Negative regulation of ubiquitin protein ligase activity →	+0.313	+1.398	<.001	<.001	3	18
URINARY_TRACT	Regulation of chromosome separation →	+0.168	+1.397	<.001	<.001	3	18
BREAST	Regulation of mitotic sister chromatid segregation →	+0.186	+1.323	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.189	+1.509	<.001	<.001	3	18
PANCREAS	Negative regulation of mitotic nuclear division →	+0.150	+0.869	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,439 associations by consensus.

Regulation of mitotic sister chromatid separation by MTFR2 expression — BREAST

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