MTFR1L

Across TCGA pan-cancer cohorts, MTFR1L Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MTFR1L data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MTFR1L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MTFR1L expression acts as an unfavorable survival marker, although some lineages such as BLCA show a favorable association.

SKCM, COAD, and LUSC are the cancer types where MTFR1L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.212	0.784	<.001	30	view →
COAD	OS	Median	III,IV	0.163	0.791	.004	12	view →
LUSC	DFS	Median	All	0.185	0.758	.010	12	view →
STAD	OS	Median	All	0.250	0.729	.028	6	view →
BLCA	OS	Median	III,IV	1.000	0.355	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MTFR1L–SKCM (OS)

Open the SKCM breakdown →