MTFR1L

Across TCGA patient cohorts, MTFR1L mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTFR1L-associated genes across cancer lineages are eIF4E, MEK1, and PRAS40_pT246. Each is linked with MTFR1L in more than 1 cancer types. Because this analysis shows association rather than direction, both MTFR1L-to-partner and partner-to-MTFR1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MTFR1L-low versus MTFR1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTFR1L→partner) and Y-score (partner→MTFR1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.273	+3.000	.025	.037	2	1
UCEC	MEK1 →	+0.574	+3.000	.006	.037	2	1
UCEC	PRAS40_pT246 →	+0.242	+3.013	.014	.019	1	1
UCEC	AMPK_pT172 →	+0.517	+3.013	.029	.019	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

eIF4E by MTFR1L expression — UCEC

Explore this box plot interactively →