MTFR1

Across TCGA pan-cancer cohorts, MTFR1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MTFR1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MTFR1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MTFR1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where MTFR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.721	0.218	.002	19	view →
CCRCC	DFS	Quartile	II,III,IV	0.223	0.828	.002	11	view →
GBM	OS	Median	All	0.798	0.935	.007	5	view →
LSCC	OS	Tertile	III,IV	0.986	0.604	.026	5	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MTFR1–LUAD (OS)

Open the LUAD breakdown →