MTFR1

Across TCGA patient cohorts, MTFR1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTFR1-associated genes across cancer lineages are Chk2_pT68, Chk2, and EGFR_pY1068. Each is linked with MTFR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTFR1-to-partner and partner-to-MTFR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by MTFR1-low versus MTFR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTFR1→partner) and Y-score (partner→MTFR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.143	-3.143	.045	.018	3	2
UCEC	Chk2 →	-0.212	-2.000	.018	.030	3	2
UCEC	EGFR_pY1068 →	-0.210	-3.169	.029	.018	3	1
UCEC	MEK1 →	+0.346	+2.321	.013	.005	3	1
UCEC	Notch1 →	+0.115	+1.750	.033	.049	3	1
UCEC	VHL →	-0.790	-1.678	.002	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Chk2_pT68 by MTFR1 expression — UCEC

Explore this box plot interactively →