MTFMT

Across TCGA patient cohorts, MTFMT mutation is significantly associated with the RNA expression of many other genes, with 227 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTFMT-associated genes across cancer lineages are TAAR5, RPL31P40, and SEPTIN7P4. Each is linked with MTFMT in more than 1 cancer types. Because this analysis shows association rather than direction, both MTFMT-to-partner and partner-to-MTFMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAAR5 grouped by MTFMT-low versus MTFMT-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTFMT→partner) and Y-score (partner→MTFMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TAAR5 →	+0.045	+3.508	<.001	.006	3	2
SKCM	RPL31P40 →	+0.084	+4.098	<.001	.001	3	2
UCEC	SEPTIN7P4 →	+0.083	+3.879	.005	.009	3	2
BLCA	ISCA1P3 →	+0.212	+5.411	<.001	.005	3	2
UCEC	MIR6769B →	+0.472	+3.437	<.001	.004	3	2
UCEC	LINC02336 →	+0.096	+3.811	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 227 associations by consensus.

TAAR5 by MTFMT expression — SKCM

Explore this box plot interactively →