MTFMT

Across TCGA patient cohorts, MTFMT mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTFMT-associated genes across cancer lineages are JNK_pT183_Y185, Bak, and Caspase-7-cleavedD198. Each is linked with MTFMT in more than 1 cancer types. Because this analysis shows association rather than direction, both MTFMT-to-partner and partner-to-MTFMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MTFMT-low versus MTFMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTFMT→partner) and Y-score (partner→MTFMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.246	-2.986	.011	.037	3	1
UCEC	Bak →	+0.324	+3.000	.025	.037	3	1
UCEC	Caspase-7-cleavedD198 →	+0.767	+2.827	.025	.035	3	1
UCEC	Caspase-8 →	-0.302	-2.973	.038	.035	3	1
UCEC	Cyclin-E2 →	+0.216	+2.817	.026	.036	3	1
UCEC	VHL →	-1.217	-3.000	.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

JNK_pT183_Y185 by MTFMT expression — UCEC

Explore this box plot interactively →