MTF2

Across TCGA patient cohorts, MTF2 mutation is significantly associated with the RNA expression of many other genes, with 1,863 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTF2-associated genes across cancer lineages are RNA5SP412, RNA5SP447, and KRTAP2-1. Each is linked with MTF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTF2-to-partner and partner-to-MTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by MTF2-low versus MTF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTF2→partner) and Y-score (partner→MTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.589	+2.178	<.001	<.001	3	3
CESC	RNA5SP447 →	+0.349	+5.201	.004	.007	3	2
CESC	KRTAP2-1 →	+0.781	+6.569	<.001	.001	3	2
CESC	TRIM64EP →	+0.075	+5.969	<.001	.002	3	2
CESC	GPX5 →	+0.775	+5.306	<.001	.006	3	2
CESC	LINC01831 →	+0.209	+6.342	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,863 associations by consensus.

RNA5SP412 by MTF2 expression — UCEC

Explore this box plot interactively →