MTF2

Across TCGA cell cohorts, MTF2 mutation is significantly associated with the drug of many other genes, with 67 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTF2-associated genes across cancer lineages are Methotrexate, AZD1332, and RVX-208. Each is linked with MTF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTF2-to-partner and partner-to-MTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methotrexate grouped by MTF2-low versus MTF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTF2→partner) and Y-score (partner→MTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Methotrexate →	+1.103	+2.807	.004	.035	3	1
LARGE_INTESTINE	AZD1332 →	+0.505	+2.825	.038	.023	3	1
LARGE_INTESTINE	RVX-208 →	+0.494	+2.868	<.001	.022	3	1
LARGE_INTESTINE	Entospletinib →	+0.561	+2.868	.001	.022	3	1
LARGE_INTESTINE	AGI-6780 →	+0.375	+2.868	.041	.022	3	1
LARGE_INTESTINE	AZD5153 →	+0.583	+2.871	.014	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Methotrexate by MTF2 expression — LARGE_INTESTINE

Explore this box plot interactively →