Across TCGA pan-cancer cohorts, MTF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MTF1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MTF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MTF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, LSCC, and PDAC are the cancer types where MTF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.940	0.366	<.001	29	view →
LSCC	DFS	Tertile	All	0.807	0.530	.006	22	view →
PDAC	DFS	Quartile	II,III,IV	0.801	0.192	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: MTF1 tumor-vs-normal RNA expression · all MTF1 data types