MTF1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MTF1 mutation is significantly associated with the RNA expression of many other genes, with 5,297 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTF1-associated genes across cancer lineages are RNA5SP307, RNU4-63P, and FGFR3P1. Each is linked with MTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTF1-to-partner and partner-to-MTF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTF1→partner) and Y-score (partner→MTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CESCRNA5SP307 →+0.172+4.342<.001.00732
CESCRNU4-63P →+0.172+4.144.009.00932
CESCFGFR3P1 →+0.042+4.342<.001.00732
UCECRNA5SP411 →+0.858+1.616<.001<.00132
UCECRPS29P32 →+0.338+1.911<.001.00132
UCECRNA5SP412 →+0.517+2.023<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 5,297 associations by consensus.

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