Across TCGA patient cohorts, MTF1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTF1-associated genes across cancer lineages are 14-3-3_epsilon, FoxM1, and Acetyl-a-Tubulin-Lys40. Each is linked with MTF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTF1-to-partner and partner-to-MTF1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTF1→partner) and Y-score (partner→MTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	14-3-3_epsilon →	+0.184	+3.186	.005	.010	3	3
UCEC	FoxM1 →	+0.203	+1.716	.015	.003	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.356	+1.495	.031	.034	3	2
UCEC	Ku80 →	+0.244	+1.729	.001	.002	3	2
UCEC	p62 Lck ligand →	+0.336	+3.906	.001	<.001	3	2
UCEC	P-Cadherin →	-0.102	-2.000	.029	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

MTF1 survival (RNA) · tumor vs normal (RNA) · all MTF1 data types