MTERF4

Across TCGA patient cohorts, MTERF4 mutation is significantly associated with the RNA expression of many other genes, with 888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTERF4-associated genes across cancer lineages are RNASE8, AQP7P3, and LINC02559. Each is linked with MTERF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTERF4-to-partner and partner-to-MTERF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by MTERF4-low versus MTERF4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTERF4→partner) and Y-score (partner→MTERF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNASE8 →	+0.612	+3.882	<.001	<.001	3	2
UCEC	AQP7P3 →	+0.047	+3.997	<.001	.001	3	2
SKCM	LINC02559 →	+0.094	+4.039	<.001	.009	3	2
UCEC	AKR1A1 →	+0.483	+3.459	.002	.005	3	2
UCEC	GPX4 →	+0.581	+3.513	.006	.002	3	2
UCEC	INO80B-WBP1 →	+0.105	+3.477	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 888 associations by consensus.

RNASE8 by MTERF4 expression — SKCM

Explore this box plot interactively →