MTERF4

Across TCGA patient cohorts, MTERF4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTERF4-associated genes across cancer lineages are Notch1, VHL, and Tuberin. Each is linked with MTERF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MTERF4-to-partner and partner-to-MTERF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MTERF4-low versus MTERF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTERF4→partner) and Y-score (partner→MTERF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.223	+2.817	.003	.036	3	1
UCEC	VHL →	-1.245	-3.169	<.001	.019	3	1
UCEC	Tuberin →	+0.325	+3.169	.028	.020	2	1
UCEC	Ku80 →	+0.277	+3.183	.032	.010	1	1
UCEC	STAT5a →	+0.521	+3.169	.017	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by MTERF4 expression — UCEC

Explore this box plot interactively →