MTERF3

Across TCGA patient cohorts, MTERF3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTERF3-associated genes across cancer lineages are CDK1, S6_pS235_S236, and S6_pS240_S244. Each is linked with MTERF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MTERF3-to-partner and partner-to-MTERF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDK1 grouped by MTERF3-low versus MTERF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTERF3→partner) and Y-score (partner→MTERF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDK1 →	+0.202	+2.820	.004	.035	3	3
UCEC	S6_pS235_S236 →	+0.494	+2.584	.014	.011	3	2
UCEC	S6_pS240_S244 →	+0.643	+3.700	<.001	.001	3	2
UCEC	ASNS →	+0.610	+3.321	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.132	-3.301	.004	.010	3	1
UCEC	EGFR →	-0.227	-2.321	.002	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CDK1 by MTERF3 expression — UCEC

Explore this box plot interactively →