Across TCGA pan-cancer cohorts, MTDHP5 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MTDHP5’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MTDHP5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MTDHP5 is over-expressed in tumor.
LIHC and KICH are the cancer types where MTDHP5 tumor–normal differential expression is most reproducible.