MTDH

Across TCGA pan-cancer cohorts, MTDH Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MTDH data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MTDH Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MTDH expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, STAD, and SKCM are the cancer types where MTDH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.215	0.652	<.001	52	view →
STAD	OS	Median	All	0.126	0.690	<.001	51	view →
SKCM	DFS	Median	All	0.219	0.760	.003	16	view →
LUSC	DFS	Median	II,III,IV	0.245	0.719	.003	9	view →
UCEC	DFS	Median	II,III,IV	0.896	0.308	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MTDH–HNSC (OS)

Open the HNSC breakdown →